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KMID : 0356919920250040656
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Korean Journal of Anesthesiology
1992 Volume.25 No. 4 p.656 ~ p.663
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The Effects of Halothane and Verapamil on the QT intervals in the Cat
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박정현
유은숙/신양식/문봉기/김종래/강희륜
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Abstract
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Prologation of the corrected QT(QTc)has been shown to increase the period of vulnerability of the heart to arrhythmias as well as to increase the incidence of ventricular premature beats. Previous studies indicate that inhalation anesthetics may
prolong
the QTc interval, because of the decrease in slow channel-mediated current.
Therefore this study was performed to evaluate the effects of halothane and/or intervals in the cat. Adults male or female cats weighing 2~4 kg were divided into verapamil-treated group (group I), halothane-treated group(group Ⅱa) and
halothane-and
verapamil-treated group (group Ⅱb). The QTc, blood pressures and heart rates were measured with EKG lead Ⅱto compare those at pretreatment with at post-treatment.
@ES The results are follows:
@EN 1) The QTc intervals at the post-treatment period are significantly longer than those at the pre-treatment period in all groups(p<0.05).
2) In group Ⅱthe systolic and diastolic blood pressures, and the heart rates after administration were decreased(p<0.05).
3) The QTc intervals in group Ⅱb were more prolonged than in group Ⅱa(p<0.05).
4) No correlation between three different doses of verapamil and the degree of prolongation of QTc intervals was shown.
It was concluded that either halothane or verapamil prolonged the QTc intervals and simultaneous adminstration of both agents resulted in even more prolongation of QTc intervals. However, the size of dose of verapamil was not related to the
degree
of
prolongation of QTc intervals.
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